The Epothilones: An Outstanding Family of Anti-Tumor Agents Rutilius Taurus Aemilianus Thung Tjeng Hiang

Thung Tjeng Hiang

preservingtheirsti

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Sowmya Srinivasan

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The Epothilones: An Outstanding Family of Anti-Tumor Agents Rutilius Taurus Aemilianus Thung Tjeng HiangEpothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e. g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low