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in the April 1988 issue of Chemical Engineer ing magazine
intransitiver
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Evolving Concepts in Sepsis and Septic Shock Daniel W in the April 1988 issueMuch research over the past 30 to 40 years has shown that the inflammatory response, while critical for host defense during microbial infection, may itself play a central role in the pathogenesis of sepsis. Although key mediators responsible for this injury have been identified, efforts clinically to augment our conventional antimicrobial and supportive therapies during sepsis with agents modulating the inflammatory response have been unsuccessful. As
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